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Sanofi-aventis Sanofi-aventis  
For U.S. Residents Only

How to Take Apidra®

Whether you're just starting your Apidra® insulin regimen as part of your overall diabetes treatment plan, or are looking for a quick refresher, this section will show you simple, step-by-step instructions for using rapid-acting Apidra®. Watch the instructional video or read the guide below to learn proper injection techniques for Apidra®. For information regarding Apidra® use with the Apidra® SoloSTAR® pen,
click here.



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Click here to view the full transcript for the Apidra® Injection Video

A GUIDE TO GETTING STARTED WITH APIDRA®

Always start by washing your hands.

Check Apidra® to make sure it is clear and colorless. Do not use Apidra® after the expiration date stamped on the label, or if it is cloudy or if you see particles. Throw the vial away and get a new one.

DO NOT MIX APIDRA® WITH ANY OTHER TYPE OF INSULIN THAN NPH. If you are mixing Apidra® with NPH human insulin, draw Apidra® into the syringe first, inject the mixture right away. The syringe must be new and must not contain any other medicine or residue. You do not need to shake the vial before use.

Always use a new needle and syringe every time you dose. Throw them away properly. Never share needles and syringes.

PREPARING THE DOSE

Remove the cap

Remove the cap
If you are using a new vial, remove the protective cap. DO NOT remove the stopper.

Sterilize top

Sterilize top
Wipe the top of the vial with an alcohol swab. You do not have to shake the vial of Apidra® before use.

Inject air into vial

Inject air into vial
Draw air into the syringe equal to your insulin dose. Put the needle through the rubber top of the vial and push the plunger to inject the air into the vial.

Draw up dose

Draw up dose
Leave the syringe in the vial and turn both upside down. Hold the syringe and vial firmly in one hand. Make sure the tip of the needle is in the insulin. With your free hand, pull the plunger to withdraw the correct dose into the syringe.

Check for bubbles

Check for bubbles
Before you take the needle out of the vial, check the syringe for air bubbles.

Tap to release

Tap to release
If bubbles are in the medicine, hold the syringe straight up and tap the side of the syringe until the bubbles float to the top.

Eject air
Push the bubbles out with the plunger and draw the insulin back in until you have the correct dose. If you are mixing Apidra® with NPH check with your healthcare provider on how to mix.

Remove needle
Remove the needle from the vial. Do not let the needle touch anything. You are now ready to inject.


Injecting Apidra®


Inject Apidra® under your skin. Take Apidra® as prescribed by your healthcare provider.


Injection Area

Pick your spot: upper arm, thigh, or abdomen
Decide on an injection area—either upper arm, thigh, or abdomen. Injection sites within an injection area must be different from one injection to the next.
(see Rotating injection sites).

Clean skin with alcohol
Use alcohol or soap and water to clean the injection site. The injection site should be dry before you inject.

Pinch a fold of skin

Pinch a fold of skin
Pinch the skin and hold it. Insert the needle in the way your healthcare professional has shown you.

Complete the injection

Complete the injection
Administer Apidra®:

Slowly push in the plunger of the syringe all the way.
Make sure you have injected all the insulin.
Leave the needle in the skin for about 10 seconds.
Pull the needle straight out.
For several seconds, gently press on the spot where you injected yourself.

Do not rub the area.

Discard material safely

Discard material safely

Do not recap the used needle.
Follow your healthcare professional's instructions for throwing away the needle and syringe.


ROTATING INJECTION SITES

Apidra®is taken within 15 minutes before or within 20 minutes after the start of a meal. Because of how the body absorbs insulin, Apidra® is injected into the less-sensitive layer of fatty tissue just under the skin—not into the muscle.

The 3 most common areas to inject insulin are:

Areas To Inject Insulin

1. The abdomen, except for a 2-inch circle around the navel.
2. The top and outer thighs. Avoid injecting too close to the bony area above the knee.
3. The outer, upper arms. Use the outer back area of the upper arm where there is fatty tissue.

With Apidra®, injection sites may be easily rotated because whether you inject into your abdomen, thigh, or upper arm, the rate of absorption is the same for all 3 areas.

Once you've picked your area (upper arm, thigh, or abdomen), remember that sites within those areas must be different from one injection to the next.

Never inject Apidra® into muscle or too close to moles or scars. Also, be sure to rotate your injection sites as instructed by your healthcare team.

• Offer is not valid for patients participating in Medicare, Medicaid, or any other federal- or state funded benefit programs. Offer not valid in MA (except for cash-paying patients). Void where prohibited by law.

IMPORTANT SAFETY INFORMATION FOR APIDRA®

Prescription Apidra® is for adults with type 2 diabetes or adults and children (4 years and older) with type 1 diabetes to improve blood sugar control. Do not use Apidra® during a low blood sugar reaction (hypoglycemia) or if you are allergic to any of the ingredients in Apidra®. Apidra® should normally be used with a longer-acting insulin.

Apidra® SoloSTAR® is a disposable prefilled insulin pen. Needles and the Apidra® SoloSTAR® pen must not be shared.

Apidra® may also be infused subcutaneously by external insulin infusion pumps.

Apidra® has a more rapid onset and shorter duration of action than regular human insulin. When used as a mealtime insulin, Apidra® should be given within 15 minutes before or within 20 minutes after starting a meal. Do not change your dose or the type of insulin you use without talking with your treating healthcare provider. Tell your doctor about all of your medical conditions, as well as other medicines and supplements you are taking. Check your blood sugar levels while on insulin therapy, such as Apidra®.

The most common side effect of insulin therapy, including Apidra®, is low blood sugar (hypoglycemia). Other possible side effects may include low blood potassium, injection site reactions, such as changes in fat tissue at the injection site, and allergic reactions, such as itching and rash. Less common, but potentially more serious or life-threatening, is generalized allergy to insulin, including anaphylactic reactions.

When used in a pump, do not mix Apidra® with any other insulin or liquid.

If the pump or infusion set does not work right, you may not receive the right amount of insulin. Hypoglycemia, hyperglycemia, or ketosis can happen. Problems should be identified and corrected as quickly as possible. Change the Apidra® in the pump reservoir every 48 hours.

Click here for additional important information for Apidra®.

IMPORTANT SAFETY INFORMATION FOR LANTUS®

Prescription Lantus® is for adults with type 2 diabetes or adults and children (6 years and older) with type 1 diabetes who require long-acting insulin for the control of high blood sugar.

DO NOT DILUTE OR MIX LANTUS® WITH ANY OTHER INSULIN OR SOLUTION. It will not work as intended, and you may lose blood sugar control, which could be serious. Do not change your insulin without talking with your doctor. The syringe must not contain any other medication or residue. You should not use Lantus® if you are allergic to insulin. Lantus® is a long-acting insulin you inject just once a day, at the same time each day. You must test your blood sugar levels while using an insulin such as Lantus®.

The most common side effect of insulin, including Lantus®, is hypoglycemia, which may be serious. Other possible side effects may include injection site reactions, including changes in fat tissue at the injection site, and allergic reactions, including itching and rash. In rare cases, some allergic reactions may be life threatening. Tell your doctor about other medicines and supplements you are taking because they can change the way insulin works.

Click here for additional important information for Lantus®.

Click here for information on drug anti-counterfeiting.

The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.