Indications and Usage for Apidra
Prescription Apidra is a fast (rapid) acting insulin used for adults and children with
diabetes mellitus to control high blood sugar. It is not known if APIDRA is safe or
effective in children less than 4 years of age with type 1 diabetes or in children with type
When used as a mealtime insulin, Apidra should be given within 15 minutes before or within 20
minutes after starting a meal.
Apidra may be infused subcutaneously by external insulin infusion pumps.
Important Safety Information
Do not use Apidra if you have low blood sugar reaction or if you are allergic to insulin
glulisine or any of the ingredients in Apidra.
Do not share needles, insulin pens or syringes with others even if the needle is changed.
Do NOT reuse needles. You may give other people a serious infection or get a serious
infection from them.
Change (rotate) your injection sites within the area you chose with each dose to
reduce your risk of getting lipodystrophy (pitted or thickened skin) and localized cutaneous
amyloidosis (skin with lumps) at the injection sites. Do not use the same spot for
each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly,
hard, scarred or damaged.
Before starting Apidra, tell your doctor about all your medical conditions, including if you
have liver or kidney problems, if you are pregnant or planning to become pregnant or if you
are breastfeeding or planning to breastfeed.
Heart failure can occur if you are taking insulin together with
pills called TZDs (thiazolidinediones), even if you never had heart failure or other heart
problems. If you have heart failure, it may get worse while you take TZDs with Apidra. Your
treatment with TZDs and Apidra may need to be changed or stopped by your doctor if you have
new or worsening heart failure. Tell your doctor if you have new or worsening symptoms,
- Shortness of breath
- Sudden weight gain
- Swelling of your ankles or feet
Tell your doctor about all medications you take, including OTC medicines, vitamins,
supplements, and herbal supplements.
When used a mealtime insulin, Apidra should be taken within 15 minutes before a meal or
within 20 minutes after starting a meal. Test your blood sugar levels as directed by your
doctor when using Apidra. Do not change your dose or type of insulin without talking to your
doctor. Any change of insulin should be made cautiously and only under medical
Check your insulin label to verify that you have the correct insulin before each injection.
Use Apidra only if the solution is clear and colorless with no particles visible.
While using Apidra, do not drive or operate heavy machinery until you know how Apidra affects
you. Do not drink alcohol or use medicines that contain alcohol.
Apidra may cause serious side effects that can lead to death,
- Low blood sugar (hypoglycemia). Signs and symptoms of low blood sugar may include
dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred
speech, shakiness, fast heartbeat, anxiety, irritability or mood changes, hunger.
- Serious allergic reactions. Get medical help right away if you have: a rash over
your whole body, shortness of breath, trouble breathing, fast pulse, sweating or feeling
- Low potassium in your blood (hypokalemia). Your doctor should monitor you for low
blood potassium levels.
- Heart failure. Your doctor should monitor you closely while you are taking TZDs
Get emergency medical help if you have:
- Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue,
or throat, sweating, extreme drowsiness, dizziness, confusion.
The most common side effects of APIDRA include: low blood sugar (hypoglycemia), weight
gain, itching, rash, swelling, allergic reactions including injection site reactions, skin
thickening or pits at the injection site (lipodystrophy).
Important Safety Information for Apidra® (insulin glulisine injection)
Apidra SoloSTAR is a disposable single-patient-use prefilled insulin pen. Please talk to your
healthcare provider about proper injection techniques and follow instructions in the
Instruction Leaflet that accompanies the pen.
Important Safety Information for Apidra when used in a pump
Replace the infusion sets (reservoir, tubing, and catheter), and the Apidra in the reservoir
at least every 48 hours and select a new infusion site. Do not mix or dilute Apidra when
used in the pump.
Failure of your insulin pump or infusion set or degradation of the insulin in the pump can
cause hyperglycemia and ketoacidosis. Always carry an alternate form of insulin
administration in the case of pump failure.
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The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.